Journal article
Azithromycin 1.5g over 5 days compared to 1g single dose in urethral mycoplasma genitalium: Impact on treatment outcome and resistance
TRH Read, CK Fairley, SN Tabrizi, M Bissessor, L Vodstrcil, EPF Chow, M Grant, J Danielewski, SM Garland, JS Hocking, MY Chen, CS Bradshaw
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017
DOI: 10.1093/cid/ciw719
Abstract
Background. We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 and compared this to cases treated with azithromycin 1g in 2012-2013. Methods. Microbiological cure was determined for men with M. genitalium urethritis treated with azithromycin 1.5g using quantitative polymerase chain reaction specific for M. genitalium DNA on samples 14-100 days post-treatment. Pre- and post-treatment macrolide resistance mutations were detected by sequencing the 23 S gene. Results. There was no difference in proportions with microbiological cure between azithromycin 1.5g..
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Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (Early Career Fellowships 1091536 to T. R. H. R. and 1091226 to E. P. F. C., and program grant 568971).